Harrell also had three blocks and Russ Smith added 23 points for the Cardinals (16-3, 5-1 AAC), who put the game away with an 11-0 run starting in the second half.
Luke Hancock helped out with 13 points.
The Huskies (14-4, 2-3) got 30 points from Shabazz Napier.
UConn Coach Kevin Ollie was tossed from the game and escorted from the court by a police officer during Louisville's second-half run after arguing with officials over a non-call.
Ollie objected when no whistle was forthcoming when the Huskies' Niels Giffey was run into by Louisville's Wayne Blackshear.