Prather, who missed two games with a knee injury, connected on 8-of-10 shots and hauled down six rebounds as the Gators (15-2, 4-0 SEC) reeled off a ninth straight win.
Scottie Wilbekin helped out with 16 points and Patric Young added 13.
The Tigers (8-7, 0-4) were paced by Chris Denson with 21 points.
KT Harrell added 18 for Auburn.
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