Askia Booker had 13 points and six assists for the Buffaloes (15-4, 4-2 Pac 12), who took control of the game with an 18-0 run early in the first half.
Jaron Hopkins and Xavier Johnson each chipped in 10 points.
J.T. Terrell paced the Trojans (9-9, 0-5) with 19 points. Omar Oraby added 16 for USC.
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