Oklahoma State opened the game on an 11-4 run and produced 10 consecutive points later in the first half to take control.
The Cowboys made 8-of-16 from 3-point range, seven of those successful shots coming in the first half. Markel Brown chipped in 14 points and LeBryan Nash had 13.
Oklahoma State (15-2, 3-1 Big 12 Conference) held the Horned Frogs to 29 percent shooting.
Karviar Shepherd led TCU (9-7, 0-4 Big 12) with 13 points.
The teams have met 22 times and TCU has won just two of those contests.
Members of Congress to keep receiving porn magazine
Rosie O'Donnell unveils nearly 50-pound weight loss