Prince connected on 8-of-10 shots from the field for the Bears (13-2, 1-1 Big 12), who got back on the winning track after falling to Iowa State Tuesday.
Brady Heslip (15 points), Isaiah Austin (14) and Cory Jefferson (11, 14 rebounds) also reached double figures for Baylor.
The Horned Frogs (9-6, 1-2) were paced by Brandon Parrish with 16 points with six rebounds.
Kyan Anderson added 12 points and seven assists.
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