Pinkston connected on 8-of-12 shots from the field and Ennis made 4-of-5 from 3-point range as the Wildcats (13-1, 2-0 Big East) won a second straight on the heels of a Dec. 28 loss to No. 2 Syracuse.
Villanova drained 14-of-26 from beyond the arc overall.
Darrun Hilliard helped out with 15 points.
The Friars (10-5, 0-2) were led by Bryce Cotton, who logged 25 points, six assists and six rebounds.
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