Nino Williams chipped in 15 points as the unranked Wildcats (11-3, 1-0 Big 12) reeled off a ninth straight win in the two teams' conference opener.
Thomas Gipson notched a double-double of 10 points and 11 rebounds.
The Cowboys (12-2, 0-1) got 20 points from Le'Bryan Nash but couldn't prevent the end of their five-game winning streak.
Markel Brown supplied 16 points with nine rebounds and Marcus Smart had 15 for OSU.
Swim Week Miami Beach 2014 [PHOTOS]