Taurean Prince added 16 off the bench and Isaiah Austin chipped in 15 as Baylor (11-1) completed a perfect 5-0 mark in December.
Prince and Austin teamed up for 20 of the Bears' first 28 points to help build a 36-25 halftime lead and Jefferson helped seal the win with the first six Baylor points after the break.
Oral Roberts (6-7) was paced by Shawn Glover with 22 points.
Denell Henderson contributed 16 with eight rebounds.
Swim Week Miami Beach 2014 [PHOTOS]