JayVaughn Pinkston contributed 14 points and Darrun Hilliard added 13 for the Wildcats (11-0), who are having their best start since the 1961-62 season.
The romp over Rider followed similar blow-out victories over Pennsylvania, Saint Joseph's and La Salle.
Villanova next plays third-ranked Syracuse.
Anthony Myles scored a game-high 22 points for the Broncs (5-5).
Celebrity Breakups and divorces of 2014 [PHOTOS]