Thomas Gipson contributed 14 points and Wesley Iwundu helped out with 13 as the Wildcats (8-3) notched their first victory over a ranked team.
The Bulldogs (10-2) got 14 points from Kevin Pangos but it wasn't enough to prevent their first loss in seven games.
Drew Barham added 13 while David Stockton and Przemek Karnowski supplied 10 each for Gonzaga.
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