Harrell was good on 9-for-10 shot from the field en route to 20 points and Jones added 19 for the Cardinals (8-1), who reached the 100-point mark for the first time since their memorable 104-101, five-overtime loss to Notre Dame last season.
Russ Smith scored 16 points and Wayne Blackshear netted 15 for Louisville, which shot 61.3 percent from the field.
The Ragin' Cajuns (6-3) got a game-high 25 points from Shawn Long.
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