Williams grabbed six rebounds and Farrell dished off seven assists for the Hoosiers (5-0), who shot 53.1 percent from the field in the 2K Sports Classic matchup at Madison Square Garden.
Noah Vonieh added 18 points and nine rebounds and Will Sheehey chipped in with 16 points for Indiana, which posted a 50-37 halftime lead and cruised from there.
The Hoosiers face No. 18 Connecticut Friday.
Justin Wilcox finished with a game-high 24 points for the Huskies (2-2).