Jabari Parker contributed 21 points, rebounds and had six blocks for the Blue Devils (4-1), who now advance to the tournament semifinals next week in New York.
Quinn Cook notched a double-double of 14 points and 10 assists as Duke reeled off a 105th consecutive home win against non-conference opponents.
Eastern Carolina (4-1) was paced by Prince Williams with 15 points, five rebounds and six assists.
Antonio Robinson and Akeem Richmond each added 13 points.
Celebrity Couples of 2014 [PHOTOS]