Jabari Parker contributed 21 points, rebounds and had six blocks for the Blue Devils (4-1), who now advance to the tournament semifinals next week in New York.
Quinn Cook notched a double-double of 14 points and 10 assists as Duke reeled off a 105th consecutive home win against non-conference opponents.
Eastern Carolina (4-1) was paced by Prince Williams with 15 points, five rebounds and six assists.
Antonio Robinson and Akeem Richmond each added 13 points.
Boston schools pull out free condoms over wrapping complaints
Millions of Getty images now available for free via embed tool