Grant dished off six assists and Sherman grabbed eight rebounds for Notre Dame (2-0), which began the game with a 17-3 run and was never headed.
The Fighting Irish canned 9-of-14 three-pointers during a first-half surge and went into halftime with a 51-21 lead.
Stetson (0-2) was paced by freshman Brian Pegg with 13 points.
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