Smith dealt out five assists and Chris Jones scored 12 points to go with six rebounds for the Cardinals (1-0).
Wayne Blackshear had 11 points and six rebounds, and Montrezl Harrell finished with 10 points and eight redounds for Louisville.
Canyon Barry paced the Cougars (0-1) with 10 points. Adjehi Baru had eight points and nine rebounds for Charleston.
Celebrity Breakups and divorces of 2014 [PHOTOS]