Enfield, 43, shot to prominence this season, his second at UFGC, when the Eagles won a school record 26 games, and then -- in just their second year of NCAA Division I post-season eligibility -- knocked off second-seeded Georgetown and seventh-seeded San Diego State before losing to Florida in the South Regional tournament semifinals.
USC Athletic Director Pat Haden made the announcement in a post on the school's website Monday.
"Andy's success this season at Florida Gulf Coast was not a flash in the pan," Haden said. "He has a consistent and proven record of success for more than 15 years in college and the NBA. He is a respected teacher who develops his players on the court and sees them excel in the classroom, he is a noted shooting coach, he is a relentless recruiter and he has integrity and great character."
Haden said Enfield's "brand of basketball -- an up-tempo offense and a stingy defense -- is fun for players to play and fans to watch."
Enfield's teams -- which fans came to refer to as "Dunk City" -- were 41-28 in his two seasons at FGCU.
He previously worked as an assistant coach at Florida State, as a shooting coach for the NBA Milwaukee Bucks and as an assistant coach with the Boston Celtics.
Enfield, succeeds Kevin O'Neill, who was fired in February before the team completed a disappointing 14-18 regular season and did not get past the first round of the Pac-12 tournament.
Citing sources within USC, the Los Angeles Times said Enfield signed a six-year deal worth more than $1 million per year. He was making $157,000 at Florida Gulf Coast.