C.J. Fair added 13 points and five rebounds while Michael Carter-Williams helped out with 12 and 10 rebounds in the East Region final.
The Orange (30-9) reeled off their seventh win in eight games and reached the Final Four for the first time since 2003 when they won the national championship.
Brandon Triche contributed nine points and six boards as Syracuse took a one-sided victory despite shooting just 38 percent from the field, including 5-of-17 from 3-point range.
The Orange's tenacious defense, however, produced eight blocked shots and 13 Marquette turnovers.
The Golden Eagles (26-9) were paced by a combined 28 points and 12 rebounds from Vander Blue and Davante Gardner.