Erik Murphy scored 15 points as the third-seeded Gators (28-7) gained their third consecutive Sweet 16 appearance.
Scottie Wilbekin had 12 points and six assists for Florida, which will play 15th-seeded Florida Gulf Coast at the South Regional semifinals.
Andre Hollins paced the 11th-seeded Golden Gophers (21-13) with 25 points, including and six 3-pointers. Trevor Mbakwe provided 11 points and six rebounds for Minnesota.
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