With the Aggies (20-16) clinging to a one-point margin, Sanders drove the baseline as time wound down in a bid for a game-winning lay-in, but Witter forced him to put up a bad shot, sealing the win in the opening game of the 2013 NCAA Men's Basketball Tournament.
Jeremy Underwood went 6-of-6 from the field en route to 19 points and Bruce Beckford connected on 8-of-10 shots for 16 as the Aggies racked up their fifth straight victory.
Davon Marshall made six 3-pointers while posting 22 points for the Flames (15-21).
Sanders finished with 21 points and nine assists.
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