Holloway also grabbed eight rebounds while Marshall Henderson scored 18 of his 21 points in the first half as Ole Miss (26-8) staged a big comeback to erase a 14-point deficit.
The Rebels' first conference tourney championship since 1981 ensured they would receive an invitation to the NCAA Tournament after coming into the contest as a "bubble" team.
The SEC regular season champion Gators (26-7) were led by Mike Rosario with 18 points and nine rebounds.
Kenny Boynton also reached double figures with 13 points, but missed a potential score-tying 3-pointer at the buzzer.
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