D'Vauntes Smith-Rivera added 15 points and Otto Porters scored 10 in the runaway, which slotted the Hoyas (24-5, 14-4 Big East) into the top seed in the conference tournament.
Michael Carter-Williams led Syracuse (23-8, 11-7) with 17 points. C.J. Fair added nine in the loss, the fifth in four games for the Orange.
Georgetown jumped out to a 25-18 lead and ended up shooting 42 percent from the field to 32.6 percent for Syracuse.
The Orange was 1-for-11 from 3-point range and committed 14 turnovers to Georgetown's 10.
No. 17 Marquette beat St. John's 69-67 Saturday to win a share of the Big East Conference title with Georgetown.