Curry provided 20 points with five rebounds while Kelly added 18, nine and five assists for the Blue Devils (26-4, 13-4 ACC), who racked up their fourth win in five contests.
Mason Plumlee chipped with 14 points, seven boards and five helpers and Quinn Cook donated 14 points with six boards for Duke.
The Hokies (13-17, 4-13) got 25 points from Erick Green in the loss.
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