Gorgui Dieng supplied 11 points and nine rebounds while Peyton Siva also netted 11 as the Cardinals (25-5, 13-4 Big East) reeled off their sixth consecutive win.
Louisville -- which trails Big East-leading Georgetown by one-half game -- also unleashed a tough defense en route to the victory, holding their opponents to just 29.2 percent shooting in the second half.
The Bearcats (20-10, 8-9) were led by Cashmere Wright with 15 points.
S. Carolina GOP Governor Nikki Haley breaks wood with hands [VIDEO]
Nativity scenes to be moved at Guantanamo after troops' protest