Sulaimon drained 10-of-15 shots while Plumlee cleaned up at the free throw line, connecting on 11-of-15 foul shots, and hauled down 15 rebounds as the Blue Devils (24-3, 11-3 ACC) posted their second straight one-sided win.
Seth Curry supplied 12 points and Quinn Cook also reached double figures with 11 for Duke.
Boston College (12-15, 4-10) was led by Ryan Anderson with 23 points.
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