Mike McCall added 15 points and Dwayne Evans 14 for the Billikens (20-5, 9-2 A-10), who moved into sole possession of first place in the Atlantic 10.
Saint Louis shot 55 percent from the field and committed only nine turnovers against a Virginia Commonwealth (21-6, 9-3 A-10) varsity that leads the nation in forced turnovers.
Virginia Commonwealth was an equally respectable 10 turnovers and won the battle of the boards 31-27, but shot 44.4 percent from the field and was 8-for-15 from the free throw line.
Juvonte Reddic led VCU with 19 points and 12 rebounds for his sixth double-double in eight games. The Rams saw their five-game winning streak come to a close.
Saint Louis led from the opening tip, taking a 17-0 lead and staking a 38-21 at halftime.