Wayne Blacksher and Chane Behanan each provided 12 points as the Cardinals (21-5, 9-4 Big East) triumphed for the fifth time in six contests.
Gorgui Dieng provided 10 rebounds and five blocked shots as Louisville moved 1/2 game behind Big East Conference co-leaders Syracuse, Georgetown and Marquette with the victory.
The Bulls (10-15, 1-12) were led by Jawanza Poland with 11 points.
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