Marcus Smart pumped in a career-high 28 points, going 11-of-14 from the free throw line, as Cowboys (19-5, 9-3 Big 12) recorded their seventh consecutive victory.
Markel Brown also played a key role in the triumph, supplying 14 points, six rebounds three assists and three steals.
The Sooners (16-8, 7-5) got 18 points and 15 rebounds from Romero Osby but still saw their two-game winning streak snapped.
Sam Groom and Steven Pledger also netted 18 points each in Oklahoma's loss.
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