Derrick Nix finished with 13 points and 10 rebounds for the Spartans (22-4, 11-2 Big Ten), who recorded their fifth straight win.
Gary Harris scored 14 for Michigan State.
Dylan Talley led the Cornhuskers (12-14, 3-10) with 28 points and Shavon Shields had 19 points and 12 rebounds.
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