Davante Gardner contributed 14 points and Jamil Wilson added 13 for the Golden Eagles (18-6, 9-3 Big East), who rebounded after a Monday loss to Georgetown to sweep their season's series from Pittsburgh.
Trent Lockett also reached double figures with 11 points in the victory.
The Panthers (20-6, 8-5), meanwhile, saw their three-game winning streak snapped despite 19 points from Lamar Patterson.
Tray Woodall supplied 10 points and eight assists in the loss.
Celebrity Breakups and divorces of 2014 [PHOTOS]