Phil Forte chipped in with 14 points and Mike Cobbins contributed 13 and 12 rebounds as the Cowboys (18-5, 8-3 Big 12) reeled off their sixth straight win.
Marcus Smart also reached double figures with 10 points in the one-sided victory.
The Red Raiders (9-13, 2-9) were led by Dusty Hannahs with 14 points.
Josh Gray added 10 for Texas Tech.
Celebrity Couples of 2014 [PHOTOS]