Phil Forte chipped in with 14 points and Mike Cobbins contributed 13 and 12 rebounds as the Cowboys (18-5, 8-3 Big 12) reeled off their sixth straight win.
Marcus Smart also reached double figures with 10 points in the one-sided victory.
The Red Raiders (9-13, 2-9) were led by Dusty Hannahs with 14 points.
Josh Gray added 10 for Texas Tech.
Boston schools pull out free condoms over wrapping complaints
Aaron Carter is still in love with Hilary Duff