The Hurricanes (20-3, 11-0 ACC) remained unbeaten in conference play with the help of Reggie Johnson, who went 5-of-5 from the field on his way to 14 points.
Johnson also grabbed eight rebounds.
Durand Scott (13 points) and Julian Gamble (10) made big contributions as well in Miami's 12th straight victory overall.
The Seminoles (13-11, 5-6) got 15 points and seven rebounds from Okaro White.
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