Oladipo also hauled down eight rebounds while Cody Zeller provided 24 points and eight boards as the Hoosiers (21-3, 9-2 Big Ten) rebounded from a Thursday loss to Illinois.
Christian Watford drained four shots from long range on his way to 20 points for Indiana, which posted its first victory in Columbus since 2008.
The Buckeyes (17-6, 7-4), meanwhile, got 26 points and seven rebounds from Deshaun Thomas but dropped a second straight.
Aaron Craft provided 16 points and six boards in the setback.
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