Phil Pressey helped out with 22 points as the Tigers (17-6, 6-4 SEC) improved to 81-4 at Mizzou Arena since its opening in 2004.
Keion Bell scored 21 points for Missouri, which ran its 2012-13 home record to 14-0.
The Rebels (18-5, 7-3) got 16 points each from Jarvis Summers and Marshall Henderson. Ladarius White contributed 13 points for Ole Miss, which has lost three of its last four games.
Celebrity Breakups and divorces of 2014 [PHOTOS]