Phil Pressey helped out with 22 points as the Tigers (17-6, 6-4 SEC) improved to 81-4 at Mizzou Arena since its opening in 2004.
Keion Bell scored 21 points for Missouri, which ran its 2012-13 home record to 14-0.
The Rebels (18-5, 7-3) got 16 points each from Jarvis Summers and Marshall Henderson. Ladarius White contributed 13 points for Ole Miss, which has lost three of its last four games.
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