The pair combined to go 14-of-19 from the field and Pangos nailed four 3-pointers in the winning effort, which saw the Bulldogs (23-2, 10-0 WCC) defeat the Lions at home for the 23rd straight time.
Gonzaga's Elias Harris recorded 16 points and 10 rebounds.
Loyola (8-16, 1-10) managed only 29.8 percent shooting from the field in dropping its eighth straight overall.
Anthony Ireland paced the Lions with a game-high 30 points.
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