Smith provided 18 points and five rebounds while Siva contributed 14 points and seven assists for the Cardinals (18-4, 6-3 Big East), who shot 51.9 percent from the field in winning their second straight following a three-game skid.
Gorgui Dieng chipped in with eight points and eight boards for Louisville.
Vander Blue finished with 17 points and Trent Lockett supplied 16 as the Golden Eagles (15-5, 6-2) lost for the second time in four contests.
Interpol investigating stolen passports on missing flight
Susan Sarandon 'very excited' about daughter's pregnancy