Akil Mitchell provided 14 points and 12 rebounds as the Cavaliers (15-5, 5-2 ACC) recorded their fourth straight victory.
The Wolfpack (16-5, 5-3) got 20 points and 14 rebounds from C.J. Leslie but couldn't avoid falling to 0-5 all-time at the 6-year-old John Paul Jones Arena in Charlottesville.
Richard Howell scored 12 points and grabbed 11 rebounds for N.C. State.
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