Trent Lockett added 10 points and eight rebounds for the Golden Eagles (15-4, 6-1 Big East), who reeled off their 21st straight home win and claimed a share of the Big East lead.
Blue pumped in 21 of his in the second half, helping Marquette pull away for the victory.
USF (10-10, 1-7) was led by JaVontae Hawkins with 14 points.
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