Phil Pressey had 12 points and six assists for the Tigers (15-4, 4-2 SEC), who won their fifth straight in the absence of leading scorer Laurence Bowers, who was averaging 16.8 points per game before spraining a knee ligament this month against Alabama.
Missouri used a 32-2 surge in the first half to put the contest away.
Rod Odom led Vanderbilt (8-10, 2-4) with 17 points.
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