Jeff Withey finished with 13 points, nine boards and four blocks as the Jayhawks (18-1, 6-0 Big 12) improved on the nation's longest winning streak.
Travis Releford had 10 points, five rebounds, five assists, and Elijah Johnson and Naadir Tharpe scored eight points apiece for Kansas.
Amath M'Baye and Romero Osby scored 12 points each for the Sooners (13-5, 4-2), who lost for the 12th consecutive time on the road to Kansas.
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