Harris contributed 12 points and pulled down 11 rebounds while Kevin Pangos helped out with 11 points as the Bulldogs (19-2, 6-0 WCC) maintained a perfect conference record.
Chris Adams netted nine points for the Dons (9-12, 2-6), who lost on the road against Gonzaga for the 24th straight time.
Avry Holmes added eight for San Francisco.
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