Murphy hauled down six rebounds. Patric Young hit all six of his shots from the field en route to 13 points and added six boards as Florida (16-2, 6-0 SEC) reeled off its eighth straight victory.
Scottie Wilbekin chipped in with 13 points and nine assists for the Gators.
Fred Thomas led the Bulldogs (7-11, 2-4) with 19 points and seven steals. Colin Borchert scored 10 points for Mississippi State.