Christian Watford (14 points, six rebounds) and Jordan Hulls (15 points) also reached double figures for the Hoosiers (16-2, 4-1 Big Ten), who bounced back from a Tuesday loss to Wisconsin.
Victor Oladipo helped out with seven points and six boards for Indiana.
The Wildcats (11-8, 2-4) were led by Reggie Hearn with 22 points.
Jared Swopshire added 13 and eight rebounds for Northwestern.
Notable deaths of 2014 [PHOTOS]