Brandenberg finished with 22 points and six rebounds while Graham provided 20 points for the Rams (16-3, 4-0 A-10).
Juvonte Reddic went 8-of-10 from the field for 16 points for Virginia.
The Dukes (7-11, 0-4) were led by Derrick Colter's 15 points.
Quevyn Winters also reached double figures with 12 points for Duquesne.
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