Carter-Williams scored 11 of his 16 points during the final 7 1/2 minutes and recorded seven assists, sending the Orange (17-1, 5-0 Big East) to their seventh straight win and fifth consecutive Big East triumph.
Brandon Triche hit five 3-pointers en route to 23 points for Syracuse.
Louisville (16-2, 4-1), meanwhile, saw its 11-game winning streak snapped despite 25 points from Russ Smith.
Chane Behanan added nine points and 11 rebounds for the Cardinals.
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