Lyons drained 8 of his 15 shots for the Wildcats (16-1, 4-1 Pac-12), who tuned up for their Thursday meeting against No. 25 UCLA with a second straight victory.
Solomon Hill finished with 13 points, six rebounds and five assists for Arizona.
Jahii Carson scored 22 and Evan Gordon scored 14 for the Sun Devils (14-4, 3-2) who have lost two straight games.
Swim Week Miami Beach 2014 [PHOTOS]