Cody Zeller added 18 points for the Hoosiers (15-1, 3-0) who built up a 52-29 halftime lead and were able to withstand a second-half comeback by Minnesota (15-2, 3-1).
Minnesota rallied for 52 points in the second half but lost for the first time since a Thanksgiving Day loss to Duke.
Andre Hollins led the Gophers with 25 points, including five 3-point shots.
Indiana shot 50 percent from the field, including 8-of-10 by Oladipo and 4-of-7 from 3-point range by Hulls.
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