The Panthers (13-3, 1-2 Big East) shot 55.1 percent from the field in the upset over the Hoyas (10-3, 0-2), who went 13-for-36 from the field and missed all but two of their 11 attempts from 3-point territory.
The loss was the second in a row for Georgetown, who shot 36.1 percent from the field. Pitt ended its own two-game losing skid.
Otto Porter led Georgetown with nine points and Nate Lubik scored seven. Georgetown trailed 37-22 at intermission and could get no closer than 21 points down the stretch.