McDermott provided 16 points and seven rebounds while Manigat contributed 13 points and five assists as the Bluejays (15-1, 4-0 MVC) reeled off their ninth straight win.
Creighton also got 10 points, five boards and four assists from Grant Gibbs in the triumph.
The Bulldogs (6-9, 0-4) were paced by Joey King with 17 points.
Micah Mason and Jordan Clarke each added 11 in the loss.
Toddler uninjured after being knocked over by Obama family dog
Gal Gadot cast as Wonder Woman for 'Batman vs. Superman'