James Southerland helped out with 17 points while C.J. Fair added 10 and 10 rebounds for the Orange (14-1, 2-0 Big East).
Syracuse won despite managing to shoot only 36.5 percent from the field, including 4-of-17 from 3-point territory.
South Florida (9-4, 0-1) fell despite getting 15 points and 11 boards from Victor Rudd in its conference opener.
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Toddler uninjured after being knocked over by Obama family dog